Timing of streptoccal serology testing for evidence of preceding Group A streptoccal infection is important. Streptococcal antibodies rise during the first month after infection, plateau for 3-6 months before returning to normal levels at 6-12 months.
Microbiology - Serology
Chilled (2 - 8 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)
Preferred aliquot serum 2 mL
The cutoff values for serological evidence of Group A streptococcal disease vary dependent on the individual assay used by the laboratory. The reported values may deviate from those stated in the Ministry of Health Rheumatic Fever guideline.
Please Note: Method Change for Streptococcal DNAse B as from 12.06.2023. Fully quantitative results are now reported using Siemens N Latex assay by
nephelometry on Siemens BNII. Significant range >=200 U/ml across all age ranges.
Interpret in conjunction with Anti-Streptolysin O result.
Reported in international units per mL:
Normal Dnase B <200 for adults and <300 for school age children.
ASO DNASE B
<200 IU/ml <200 IU/ml ADULTS
<250 IU/ml <200 IU/ml School Age children
<100 IU/ml <200 U/ml Pre-school children
Semi-quantitative Colourimetric Assay
$40.83 (Exclusive of GST)
Onset date of illness desirable.
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