Interpretation
An interpretive comment is provided with the report.
If a monoclonal band is detected, immunofixation will be performed to identify the abnormal immunoglobulins involved. The monoclonal band will be quantitated by densitometric scanning of the gel using the perpendicular drop gating method.
A qualitatively normal but elevated gamma fraction (polyclonal increase in immunoglobulins) is consistent with infection, liver disease, or autoimmune disease.
Decreased immunoglobulins (hypogammaglobulinaemia) is consistent with immune deficiency and can also be associated with primary amyloidosis or nephrotic syndrome.
An absent or reduced alpha-1 fraction is consistent with alpha-1 antitrypsin deficiency and further testing will be suggested if clinically indicated.
A raised alpha-1 and or alpha-2 fraction are indication of a recent or current inflammatory process.
A low alpha-2 fraction can be indicative of haemolysis or liver disease. Haptoglobin testing is added if this is noted.
Test Method
MYELOMA SCREEN includes the following tests:
Serum Protein Electrophoresis
Immunoglobulin Quantitation (IgG, IgA, IgM)
Serum Free Light Chains
Total Protein
Albumin
