Thyroglobulin, Serum

Diagnostic Use

Post-operative monitoring in differentiated thyroid carcinoma (DTC).

Department

Endo/Steroid Lab

Delphic Registration Code

TG

Synonyms

Tg

Turnaround Time

4 days

Test Code

6580

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• SST II (Gold Cap)

Preferred Sample Volume (ml)

2

No of Samples Required

1

Additional Specimen Information

Pre-Testing Requirements:
Take samples pre or >2 wks post any fine needle aspiration.

Patients who are undergoing biotin therapy and/or ingesting biotin supplements with levels of >100ng/mL will show a falsely low Thyroglobulin result in the Beckman Thyroglobulin assay.

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

1.0

Transport to Lab

Ambient (8 - 24 degrees Celsius)
If overnight - Frozen

Interpretation

Serum thyroglobulin should be undetectable (<0.1 µg/L) in a patient who has had a total thyroidectomy and has a TSH <0.1 mIU/L.

Anti-thyroglobulin antibodies (TgAb), even at low titre, may interfere with thyroglobulin measurement to cause falsely low or undetectable Tg levels.

There is evidence in patients with DTC that an increase in serum TgAb on serial sampling is a risk factor for disease recurrence.

Reference Intervals

<0.1 – 58 µg/L in serum

Test Method

Beckman Coulter Access

Non-Funded Test Cost

$36.97 (Exclusive of GST)

Billing Code

6580

1. Test includes a screen for potentially interfering Tg autoantibodies (TgAb).

2. Serum is the recommended specimen, although serum or lithium heparin plasma may be used for Tg measurement, lithium heparin is not suitable for TgAb test.

Contact Information

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