An adjunct test to cytological examination of fine needle aspiration specimens in athyrotic individuals treated for differentiated thyroid carcinoma (DTC). FLuids other than saline washes require prior consultation with a CHLabs Pathologist.
Specimen Collection Protocols:
After biopsy and expulsion of the material for cytology:
1. Wash each needle from a single lymph node nodule with 0.1 - 0.5 ml lots of normal saline, then combine the washings from a single node into a tube and cap it. The recommended volume is 0.5 - 1.0 ml per node, maximum 1.5 ml.
2. Centrifuge the specimen if there is visible blood or tissue. Transfer supernatant to a new tube.
3. Freeze for transport.
If more than one node is biopsied, the washings from each node must be submitted as separate specimens.
If overnight - Frozen
1.0 - 1.5 ml
1. A recent study reported that a TG cut-off of 1 ug/L for FNA-needle wash specimens provided 100% sensitiviy and 96.2% specificity for the detection of metastatic thyroid carcinoma in lymph nodes – refer J.CLin.Endocrinol.Metab. 2007; 92 (11): 4278 – 4281. This cut-off applies only to total needle wash volumes of <1.5 ml of normal saline.
2. FNA-TG levels should not be interpreted as absolute evidence of presence or absence of malignant disease. Results should be used in conjunction with clinical evaluation, cytology and imaging procedure information.
3. The test has been validated only in single lymphnodes from athyrotic patients.
4. FNA-TG should not be used to screen asymptomatic individuals for neoplastic disease.
5. TG may be undetactable in some undifferentiated metastases and cytology should be performed.
6. The adequacy of the biopsy sample, wash volume and matrix may affect the reported TG concentration.
Beckman-Coulter Access analyser (ICMA)
$108.35 (Exclusive of GST)
Uncertainty of Measurement:
0.1 ug/L for 1 ug/L
Urgent testing by arrangement
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