To assist in the investigation of suspected adrenal insufficiency.
SST can also be useful in the characterisation of 21-hydroxylase deficiency (Congenital Adrenal Hyperplasia).
After a basal cortisol blood test is taken, Synacthen is administered to stimulate the secretion of cortisol from the adrenal glands. Cortisol is then taken again at one or two time points (30 or 60 mins) post administration. Inadequate response to Synacthen indicates adrenal insufficiency and warrants further investigation.
Endocrine Test Centre
SCO1 (pre) SCO2 (post)
ACTH stimulation test
Withhold any treatment with steroids for 24 hours prior to test.
Ambient (8 - 24 degrees Celsius)
If overnight - Frozen
A cortisol result of >400nmol/L post Synacthen administration indicates adequate response to Synacthen and suggests normal adrenal reserve.
A post synacthen cortisol of <400nmol/L suggests adrenal insufficiency (primary or secondary) and warrants further evaluation by an endocrinologist.
Competitive ECLIA Roche Cobas E411.
Please contact the Endocrine Test Centre for Synacthen protocol (80934).
"*" indicates required fields