Anti-Proteinase 3 (PR3) antibodies are primarily associated with ANCA-associated vasculitis, most specifically Granulomatosis with Polyangiitis (GPA).
Presence of antibodies aids diagnosis; patients with known disease use antibody concentrations over time for prognostic indication and may be useful in identification of disease flare and remission.
The clinical relevance of anti-PR3 outside of vasculitis (e.g. inflammatory bowel disease or primary sclerosing polyangiitis) is uncertain.
Anti-PR3, with anti-MPO is automatically reflexed internally from indirect immunofluorescence ANCA testing.
For urgent/rapid testing please telephone the Immunology laboratory.
Please note method change from 27/10/2023; different measurement units apply, quantitative results between methods are NOT comparable.
Ambient (8 - 24 degrees Celsius)
300 uL serum (minimum), 1 mL serum (preferred)
Elevated levels of either PR3-ANCA are highly predictive of a primary small vessel necrotizing vasculitis typically within the spectrum of Granulomatosis with polyangiitis (GPA) Microscopic polyangiitis (MPA) or an overlap syndrome. They may also be associated with drug induced Vasculitis, eg. D-penicillamine, Propylthiouracil and Minocycline associated Systemic Necrotising Vasculitis.
Normal: <20 CU
Positive: >20 CU
$55.00 (Exclusive of GST)
Proteinase 3 antibodies (PR3-ANCA) are tested on all positive ANCA samples
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