Posaconazole, Serum

Diagnostic Use

Antifungal medication

Department

Toxicology

Delphic Registration Code

POSA

Turnaround Time

72 hours

Test Code

8597

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Preferred Sample Volume (ml)

4.0

No of Samples Required

1

Additional Specimen Information

Specimens should be collected predose if possible.
Do NOT use gel tubes for this analysis
State dose, dose interval and time of last dose on request form.

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

0.5

Transport to Lab

Chilled (2 - 8 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)

Additional Referral/Aliquot Information

State dose, dose interval and time of last dose on request form.

Reference Intervals

Trough concentrations >1mg/L are effective for treating most fungal infections.

For prophylaxis, trough concentrations >0.5 mg/L are recommended.

Toxicity rare, though increased at >5 mg/L

Patients with hypoalbuminaemia have a higher free posaconazoleconcentration for a given total itraconazole concentration.

Posaconazole inhibits drug metabolism, increasing exposure to multiple other drugs.

Test Method

LC-MSMS

Non-Funded Test Cost

$213.17 (Exclusive of GST)

Billing Code

8597

Contact Information

Enquiry Form