P1NP

Diagnostic Use

P1NP (total procollagen type 1 N-terminal propeptide) is the preferred marker for bone formation. It is a specific indicator of type 1 collagen deposition. It is released as a trimeric structure, but degrades to a monomer. The Elecsys assay detects both, ie. total P1NP.

It is increased in states of high bone turnover and hence may be of value for assessing the response to treatment of osteoporosis and Paget's disease.

Has been reported to be a marker for bone metastases of several types of carcinoma.

Department

Endo/Steroid Lab

Delphic Registration Code

PINP

Synonyms

procollagen type 1 N-terminal propeptide, PINP

Turnaround Time

7 days

Test Code

8382

Specimen Type

• Serum
• Plasma

Specimen Requirements

Tube/Container Type:

Preferred

• EDTA (Lavender Cap)

Acceptable

• Serum (Red Cap)
• SST II (Gold Cap)
• Lithium Heparin - Non-gel (Green Cap)
• Lithium Heparin - Gel (Green Cap)

No of Samples Required

1

Paediatric Specimen Requirements

Tube/Container Type:

Preferred

• EDTA (Lavender Cap)

Acceptable

• Serum (Red Cap)
• SST II (Gold Cap)
• Lithium Heparin - Non-gel (Green Cap)
• Lithium Heparin - Gel (Green Cap)

Aliquot Instructions

Sample Type

• Serum
• Plasma

Minimum Volume (ml)

0.3

Transport to Lab

Frozen
If overnight - Frozen

Additional Referral/Aliquot Information

0.9 mL plasma preferred. 0.3 mL is the absolute minimum. Store frozen.

Reference Intervals

Female	Age (yrs)	ug/L
	<1	900-1800
	1 – 2	500-1500
	3 – 10	300-1000
	10 – <14	140–1200
	14 – <18	40–460
	18 – <25	20–110
	25 – <35	20–85
	35+ premenopausal	15–60
	35+ postmenopausal	20-115
Male	<1	830-1850
	1 – 2	400-1500
	3 – <12	300-900
	12 – <17	220-1600
	17 – <18	80–480
	18 – <20	60–220
	21 – <25	35–140
	25+	20-85

Test Method

Roche Cobas e411 - 2 site sandwich (immunometric)

Non-Funded Test Cost

$65.42 (Exclusive of GST)

Billing Code

8382

Evaluation of a Fully Automated Serum Assay for Total N-Terminal Propeptide of Type I Collagen in Postmenopausal Osteoporosis Patrick Garnero, Philippe Vergnaud and Nicholas Hoyle. Clinical Chemistry 54: 188-196, 2008

Contact Information

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