NIPS is a highly sensitive and specific screening test for Trisomy 21 (Down Syndrome), Trisomy 18 (Edward Syndrome) and Trisomy 13 (Patau Syndrome) performed on a sample of maternal blood. The test can be performed from the 10th week of gestation.
Testing can be performed in singleton and twin pregnancies.
Requests for NIPS are only accepted on a fully completed CHL Request form available from the laboratory.
NIPS is a screening test with a sensitivity of >99% for trisomy 21, trisomy 18 and >85% for trisomy 13. A ‘low risk’ result does not completely exclude fetal chromosomal abnormality. A ‘high risk’ result should be followed up by specialist referral for diagnostic testing.
In about 3% of tests it is not possible to provide a result due to a low concentration of fetal DNA relative to maternal DNA (low fetal fraction) and a ‘No result’ will be issued. The fetal fraction decreases with increasing maternal weight, such that the risk of a ‘No result’ is about 20% in a woman with a maternal weight of 95 kg.
STECK BCT tube must have more than 7 mL of blood ( otherwise sample is rejected ), Please check the request form and consent form are signed
please scan consent form and request form
Keep sample at room temperature, the tubes should not be separated or frozen, send to MSS lab. (80122)
Sample is stable at room temperature untill sent to VCGS
Patients & Clinicians must read & fill out the consent form & request form (found in Additional Information - Resources below). Both forms are to be given to the lab when the blood is collected.
Maternal blood collected in a 10 ml Streck BCT tube. The tube must have 7 mL of blood. The tube must be gently inverted 10 times after blood sampling. Whole blood required do not spin, or separate.
Kept at room temperature, the tubes should not be frozen.
Ambient (8 - 24 degrees Celsius)
Whole blood required do not spin, or separate
This assay is a screening test. False positive and false negative test results can occur. High risk test results require follow up by a specialist obstetrician. Low risk test results are highly accurate for excluding trisomy of chromosome 21,18 and 13 or loss of X or Y chromosomes.
Either ‘LOW RISK’ or ‘HIGH RISK’
$584.4 (Exclusive of GST)
This test is not Ministry of Health funded - patient required to pay for testing.
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