Reference Intervals
Interpretive comments
Result: Negative on serum
Comment: In NMDAR antibody associated disease specific antibodies may not be detectable in serum yet are detectable in CSF. If there is a strong clinical suspicion of NMDAR encephalitis we recommend testing of CSF. The clinical spectrum typically affects a younger age group, in both males and females (<30 years). Most patients will have a non-specific prodromal inflammatory phase progressing to a psychotic phase and neurological phase.
Result: Indeterminate on Serum
Comment: ANA and / or non-specific cytoplasmic staining present which may obscure the detection of anti-NMDAR antibodies. If there is strong clinical suspicion of NMDAR encephalitis we recommend testing of CSF. The clinical spectrum typically affects a younger age group, in both males and females (<30 years). Most patients will have a non-specific prodromal inflammatory phase progressing to a psychotic phase and neurological phase.
Result: Positive on Serum
Comment: Strongly recommend testing of CSF. CSF is less prone to false positive results.
Result: Positive on CSF
Comment: Supports a diagnosis of NMDAR encephalitis, a disorder affecting both male and females. A proportion of females have an associated ovarian teratoma or more rarely extra-ovarian tumours
Result: Negative on CSF
Comment: No support for a diagnosis of NMDAR encephalitis
Test Method
Indirect immunofluorescence on transfected HEK cell line
Serum screened at 1 in 10 & 1 in 100
CSF screened neat.