Neuronal Antibodies

Diagnostic Use

Paraneoplastic neuronal antibodies are used to support rare neurological disorders caused by an underlying (and usually undetected) malignant tumour.
Tumours that have been known to initiate paraneoplastic disorders include small cell lung carcinoma (SCLC), thymoma, neuroblastoma, and breast, ovarian, and testicular cancers.
The following panel of antibodies is tested:
Anti-Hu (ANNA-1), Anti-Ri (ANNA-2), Anti-Yo (PCA-1), Ma2 (Ta), Amphiphysin, CV2 /CRMP5, Recoverin, Sox1, titin, Zic-4, GAD65 and TR.

Serum is the preferred sample type, but CSF testing can be performed.
Note due to the extremely rare presence of paraneoplastic antibodies in CSF, in-house verification of CSF testing has been extrapolated from serum evaluation.

Department

Immunology

Delphic Registration Code

NEUR

Laboratory Handling

Phlebotomy

Serum is the preferred sample type, CSF can be tested.

Registration

NEUR

Separating

Serum minimum volume is 0.2 mL; CSF minimum volume is 0.5mL

Laboratory

Stored in the 'Manual' work flow

Synonyms

Paraneoplastic antibodies
Paraneoplastic neurological syndromes
PNS
Hu autoantibodies
Neuronal nuclear antibodies
Purkinje Cell antibodies
Yo autoantibodies

Turnaround Time

4 weeks

Test Code

6964