Paraneoplastic neuronal antibodies are used to support rare neurological disorders caused by an underlying (and usually undetected) malignant tumour.
Tumours that have been known to initiate paraneoplastic disorders include small cell lung carcinoma (SCLC), thymoma, neuroblastoma, and breast, ovarian, and testicular cancers.
The following panel of antibodies is tested:
Anti-Hu (ANNA-1), Anti-Ri (ANNA-2), Anti-Yo (PCA-1), Ma2 (Ta), Amphiphysin, CV2 /CRMP5, Recoverin, Sox1, titin, Zic-4, GAD65 and TR.
Serum is the preferred sample type, but CSF testing can be performed.
Note due to the extremely rare presence of paraneoplastic antibodies in CSF, in-house verification of CSF testing has been extrapolated from serum evaluation.
Immunology
NEUR
Serum is the preferred sample type, CSF can be tested.
NEUR
Serum minimum volume is 0.2 mL; CSF minimum volume is 0.5mL
Stored in the 'Manual' work flow
Paraneoplastic antibodies
Paraneoplastic neurological syndromes
PNS
Hu autoantibodies
Neuronal nuclear antibodies
Purkinje Cell antibodies
Yo autoantibodies
4 weeks
6964