This test analyses the MEN1, RET, and CDKN1B genes for germline variants associated with multiple endocrine neoplasia (MEN) types 1, 2 and 4. MEN1 (MEN1) is characterised by tumours of the parathyroid, pituitary and pancreatic neuroendocrine glands. MEN2 (*RET*) is associated with medullary thyroid carcinoma, phaeochromocytoma and, in MEN2A, primary hyperparathyroidism. MEN4 (CDKN1B) is a rare MEN syndrome with features overlapping MEN1. Genetic testing can assist with diagnosis, guide surveillance and management, and enable testing of at-risk family members.
Genetics - Molecular Pathology
MOLP
endocrine tumours
non endocrine tumours
MEN1
MEN2
RET
CDKN1B
4 weeks