|Trough concentrations >1mg/L are effective for treating most fungal infections.
For prophylaxis, trough concentrations >0.5 mg/L are recommended.
Toxicity rare, though increased at >5 mg/L
Patients with hypoalbuminaemia have a higher free itraconazole concentration for a given total itraconazole concentration.
Itraconazole inhibits drug metabolism, increasing exposure to multiple other drugs.