Quantitative analysis of IgM is useful for:
•Detection and monitoring of immunodeficiency
•Monitoring of IgM monoclonal gammopathies
Chilled (2 - 8 degrees Celsius)
Quantitative analysis does not distinguish between monoclonal, oligoclonal, or polyclonal elevation. Serum protein electrophoresis (SPE) and Immunofixation should be used to determine if any increase is due to the presence of a monoclonal band.
A monoclonal elevation of IgM is indicative of gammopathies such as:
•Monoclonal gammopathy of uncertain significance (MGUS)
•Other related disorders.
Oligoclonal or polyclonal elevation of IgM may arise from:
•Proliferative liver diseases (e.g. Hepatitis, cirrhosis)
•Connective tissue diseases
•Infections, acute and chronic.
Immunoglobulin levels may also be elevated if the blood is extracted from the umbilical cord of neonates where there has been an intrauterine or perinatal infection.
IgM deficiencies may be due to:
•Primary or secondary immunodeficiency.
•immunosuppression due to the presence of a plasma cell dyscrasia.
|Immunoglobulin M (IgM)||0 to < 15 Days||0.1 – 0.4|
|15 Days to < 13 Weeks||0.1 – 0.7|
|13 Weeks to < 1 Year||0.2 – 0.9|
|1 to < 19 Years||0.4 – 1.9|
|Adult||0.4 – 2.3|
Nephelometric immunoassay on Siemens BNII.
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