Elevated levels of homocysteine can be associated with an increased risk of cardiovascular disease. A meta-analysis of 27 epidemiological studies, including more than 4000 patients, estimates that a 5 umol/L increase in total homocysteine was associated with an odds ratio for coronary artery disease of 1.6 (95% CI, 1.4 to 1.7) for men and 1.8 ((95% CI, 1.3 to 1.9) for women; the odds ratio for cerebrovascular disease was 1.5 (95% CI, 1.3 to 1.9). The risk associated with a 5 umol/L increase in total homocysteine was the same as that associated with 0.5 mmol/L increase in cholesterol.
Severely elevated concentrations of total homocysteine are found in subjects with homocystinuria, a rare genetic disorder of the enzymes involved in the metabolism of homocysteine. Patients with homocystinuria exhibit mental retardation, early atherosclerosis and arterial and venous thromboembolism. Other less severe genetic defects which lead to moderately elevated levels of total homocysteine are also found.
EDTA only. Collect on ice and separate within 4 hours
Collected on ice, separate within 4hours
Specimens from patients who are on drug therapy involving S-adenosyl-methionine may show falsely elevated levels of homocysteine.
Patients who are taking methotrexate, carbamazepine, phenytoin, nitrous oxide, anticonvulsants, or 6-azauridine triacetate may have elevated levels of homocysteine due to their effect on the pathway.
Collected on ice, separate within 4h.
EDTA blood MUST be kept on ice until separated. Specimens not placed on ice immediately may exhibit 10-20% increase in homocysteine concentration.
Urgent testing by arrangement.
Total homocysteine 5.0-15.0 µmol/L
The total HCY concentration of healthy individuals will vary with age, gender, geographical area, and genetic factors. Values are typically lower for women than for men, postmenopausal women show increased values for total HCY.
A majority of literature agrees upon a range of normal values (adult male and female) between 5-15 µmol/L. Values will normally increase with age with accepted expected reference values among elderly (>60 years) of 5-20 µmol/L.
5 – 15 umol/L
Beckman DxC 700AU liquid stable Homocysteine assay
$56.89 (Exclusive of GST)
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