For diagnosis of alpha thalassaemia.
Haematology - Special Tests
Sample Delivery to Lab - ambient temperature, 4°C if overnight
Ambient (8 - 24 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)
Preferred aliquot 2 x 4.0mL EDTA whole blood minimum aliquot 2mL EDTA whole blood. Hb H is unstable, prompt delivery to CHLabs is advised.
Haemoglobin H inclusion bodies are found in the red cells of patients with alpha thalassaemia. They consist of beta-4 tetramers and are formed from excess beta chains. On exposure to brilliant cresyl blue Haemoglobin H forms multiple blue-green spherical inclusions. The number of cells containing inclusions varies according to the type of alpha thalassaemia. A diagnosis of alpha thalassaemia is confirmed using DNA analysis of the alpha globin gene.
0 = no inclusion bodies
1 = one inclusion body
2 = very occasional inclusions
3 = occasional inclusion bodies
4 = moderate inclusion bodies
5 = numerous inclusion bodies
Supravital stain with brilliant cresyl blue
$74.47 (Exclusive of GST)
Performed as part of a haemoglobinopathy/thalassaemia screen. Not performed as a standalone test.
Samples may be referred for alpha globin gene deletion analysis if indicated.
Test Availability: Mon - Fri, 0800 - 1700
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