Available tests include (but not limited to):
D20S108 (20q) deletion
Various chromosome enumeration
Current FISH Panels include:
Paediatric ALL Panel ETV6-RUNX1 fusion
4 & 10 enumeration (Double Trisomy)
CLL Panel ATM deletion
MM Panel IGH-FGFR3 fusion
Genetics - Cytogenetics
Please ensure a separate tube is taken for this test
ALL FISH panel
CLL FISH panel
FISH - 20q12 Deletion Probe
FISH - BCR/ABL1 Rearrangements
FISH - CBFB, inv(16) Rearrange
FISH - ETV6/RUNX1(TEL/AML1) Tr
FISH - MLL Rearrangements
FISH - MYC Rearrangements
Lymphoma FISH panel
Multiple Myeloma FISH panel
Send all specimens without delay at ambient temperature. Do not refrigerate, freeze or centrifuge.
Transport medium is available from the laboratory by contacting LabInfo@cdhb.health.nz
Bone Marrow •>1ml bone marrow aspirate in transport medium
•Bone marrow aspirate smear slide (2x slides)
Peripheral Blood •At diagnosis: 5-10mL Lithium Heparin (green top)
•Minimal residual disease: 10mL Lithium Heparin (green top)
Note: Whole blood is required for genetic testing; please DO NOT centrifuge blood tubes
Tumour/Lymph Node >1cm tumour/lymph node tissue in transport medium
Tumour touch preparation slide (2x slides)
Ambient (8 - 24 degrees Celsius)
DO NOT refrigerate, freeze or centrifuge
Normal and abnormal ranges have been established in-house as part of the validation process for each probe. Please contact the laboratory for further details.
Fluorescence In Situ Hybridisation (FISH) is a molecular cytogenetic technique that can be described as a’ hybrid’ of molecular genetic and conventional cytogenetic technologies. The technique combines the ability to identify a specific gene or gene region with direct visualisation of cells and/or chromosomes under the microscope.
FISH is usually applied to standard cytogenetic preparations, on glass slides and both cultured and uncultured cells can be used, unlike standard cytogenetic techniques which require actively-dividing cells. This means that a variety of specimen types can be processed successfully, even those that conventionally don’t grow well in culture, making FISH a powerful tool for the study of acquired abnormality in bone marrows, tumours and even paraffin-embedded specimens. As a complementary technique, or as a test for targeted abnormalities, FISH has expanded our capabilities for more accurate, rapid and refined cytogenetic diagnoses.
$303.48 (Exclusive of GST)
An additional charge for direct interphase preparation applies where cell culture, harvest and hold or chromosome analysis has not also been requested.
Urgent turnaround time 1-3 days by arrangement.
Uncertainty of Measurement Please contact the laboratory if you have specific queries regarding our testing.
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