Glomerular basement membrane antibodies

Diagnostic Use

Anti glomerular basement membrane antibodies are found in anti-GBM disease (Goodpasture's syndrome). Levels correlate with disease activity and often predict clinical outcome.
Testing may be required urgently together with anti-MPO, anti-PR3. For same day results Mon-Fri, business hours- testing by arrangement only - the Immunology laboratory MUST be telephoned (x89787)

Department

Immunology

Delphic Registration Code

GBM

Synonyms

GBM
GBM antibodies

Turnaround Time

1 week

Test Code

5076

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• SST II (Gold Cap)

Preferred Sample Volume (ml)

5

Minimum Sample Volume (ml)

0.3

No of Samples Required

1

Paediatric Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• SST II (Gold Cap)

Preferred Sample Volume (ml)

1

Minimum Sample Volume (ml)

0.3

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

0.3

Transport to Lab

Ambient (8 - 24 degrees Celsius)

Interpretation

Anti glomerular basement membrane antibodies are found in Goodpasture’s syndrome and levels correlate with disease activity and often predict clinical outcome. The autoantibody is directed against the NC1 domain of the α- chain of type IV collagen. Approximately 25% of patients presenting with anti GBM antibodies also present with anti-neutrophil cytoplasmic antibodies, so parallel testing is recommended.

Reference Intervals

0 – 20 CU

Test Method

Chemiluminescence
All positives and as required indirect immunofluorescence on primate tissue. Screened at 1 in 10

Non-Funded Test Cost

$85.00 (Exclusive of GST)

Billing Code

5076

Additional Costing Information

Positive GBM ELISA results will be confirmed by Indirect immunofluorescence on primate kidney.
Batched at least weekly - urgent testing by arrangement

Contact Information

Enquiry Form