Investigation of hypogonadism or delayed puberty.
1. Investigation of oligospermia or azoospermia (a raised FSH value usually indicates that the defect in spermatogenesis is gross).
2. Investigation of primary and secondary amenorrhoea.
3. Assessment of hypothalamic-pituitary function. Low serum FSH values cannot always be distinguished readily from normal values except in postmenopausal women who have higher resting values than pre-menopausal. A premenopausal value in postmenopausal women is suggestive of hypothalamic-pituitary disease.
Ambient (8 - 24 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)
Preferably >0.5 mL serum or plasma. Minimum >0.2 mL.
1. Raised values: after menopause, midcycle peak (less affected than LH), primary gonadal failure (eg Klinefelter’s syndrome, Turner’s syndrome, gonadal dysgenesis or agenesis, bilateral torsion of the testis, orchidopexy, testicular injury, premature ovarian failure, oligo or azoospermia).
2. Low values – ie repeatedly low or no response to stimulation. Hypothalamic – pituitary disease (eg pituitary ablation, pituitary tumours, craniopharyngioma, Kallmann’s syndrome etc.)
3. Serum FSH determinations generally provide a better indication of primary gonadal failure than serum LH.
4. During the menopausal transition, which may last several months or longer, FSH levels may fluctuate considerably.
5. In males, FSH tends to increase with age.
0-9 yrs 0-6.5 IU/L
10-15 yrs Levels rise during puberty towards adult range
Adult male 2-12 IU/L (age related).
Expect < 8 IU/L if <40yrs; <15 IU/L if >40yrs.
Adult female Follicular 3-10 IU/L
Mid cycle 4-25 IU/L
Luteal 2-8 IU/L
Post menopause >20 IU/L
Antenatal <1 IU/L
Competitive ECLIA Roche Cobas E411.
$14.94 (Exclusive of GST)
Female reference intervals exclude OC and HRT.
Method changed from Beckman Coulter Access to Roche Elecsys on 13/4/2011. FSH results comparable by the two methods.
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