FISH, chorionic villus (CVS)

Diagnostic Use

Referrals are funded for:

o Fetal abnormalities detected on ultrasound scan
o Maternal screening (serum or NIPS) risk is >1:50
◦Parent carries a chromosome translocation involving chromosomes 13 or 21 (e.g. Robertsonian translocation)
o Previous child or pregnancy with Down, Edwards or Patau syndrome (trisomy 21, 18 or 13)

Department

Genetics - Cytogenetics

Delphic Registration Code

CTGN

Synonyms

Chorionic villus, FISH
CVS, aneuploidy screen
Prenatal diagnosis, CVS FISH
Rapid FISH, CVS

Turnaround Time

5 days

Test Code

7928

Specimen Type

• Chorionic Villus (CVS)

Specimen Requirements

Tube/Container Type:

Preferred

• RPMI (Tissue)

Additional Specimen Information

Pre-Testing Requirements Appropriate counselling by LMC or obstetrician.

Advanced Notice
If possible, please notify us by phone/fax if you have despatched a CVS specimen.
Out of town specimens - fax the request form ensuing the courier tracking no. is visible. This is in case a specimen fails to arrive.
Please also notify us if a CVS specimen is going to arrive out of normal working hours.

All samples should be taken in a sterile manner into a universal container with CVS transport medium (ensure expiry date is valid).

Send in "Prenatal Transport" pack (see below) as soon as possible. Delay can affect cell growth. Keep at room temperature. DO NOT FREEZE.

"Prenatal Transport" packs are available from the Cytogenetics laboratory.

Patient Sample
Chromosomes + FISH requires at least 25mg clean chorionic villi (as a guide, a 4-stranded branch of villi = approx 5mg tissue).

Unacceptable Samples
Those received without patient identifiers clearly displayed on specimen containers.
Those with unsuitable or insufficient villus material.

Aliquot Instructions

Transport to Lab

Ambient (8 - 24 degrees Celsius)

Interpretation

Comment on report

Reference Intervals

Comment on report

Test Method

Rapid aneuploidy screening test using fluorescence in situ hybridisation (FISH) on uncultured chorionic villus cells with probes specific for chromosomes X, Y, 13, 18 and 21. The screen detects Down, Edwards or Patau syndrome (trisomy 21, 18 or 13 respectively) or sex chromosome aneuploidy such as Monosomy X (Turner syndrome).

This test detects 70 - 80% of all chromosome abnormalities and is offered as an adjunct to microarray or G-Banded chromosome analysis.

Non-Funded Test Cost

$838.66 (Exclusive of GST)

Billing Code

5776

All prenatal requests are treated as urgent. If a result is required with 2 days please inform the laboratory

Contact Information

Enquiry Form