DPYD genotyping

Diagnostic Use

5-Fluorouracil (5-FU) is a chemotherapy drug used for a wide variety of cancer treatments. It is metabolised by the dihydropyrimidine dehydrogenase enzyme (DPD). Variants in the DPYD gene, which encodes the DPD enzyme, can cause reduced or abolished DPD activity. When these variants are present, patients are at an increased risk of severe or fatal 5-FU toxicity.

Testing for DPYD variants aids in prediction of toxicity and chemotherapeutic responses.

Delphic Registration Code


Laboratory Handling


Please do not centrifuge or freeze blood samples. If storing blood tube prior to delivery please refrigerate at 4 degrees (transport at ambient temperature).

Constituent Tests

Turnaround Time

2 weeks

Test Code