DHAS is the predominant steroid in the adult adrenal complex and the major adrenal androgen circulating in plasma. DHAS assays have replaced urine 17 keto assays and helps diagnosis of endocrine disorders such as Cushing\'s disease, adrenal tumours and congenital adrenal hyperplasia. Elevated levels may be diagnostic in adrenal tumours and are of value in the diagnosis of virilizing tumours in hirsute women. Evidence of decreased cardiovascular disease associated with elevated DHAS especially in males has been reported. Circulating adrenal androgen sulphates decline with age.
Androsterone sulphate / epiandrostene sulphate are the major 5a reduced steroids in plasma and a parrallel assay of these allows a valid measure of 5a reductase activity.
Adrenal Androgen Sulphates
Ambient (8 - 24 degrees Celsius)
DHAS 0.5 – 12.0 umol/L Adult male/female
AoS/epiAoS < 6.0umol/L Adult male/female
Circulating levels decline with age. Our data is shown above.
$29.97 (Exclusive of GST)
Uncertainty of Measurement:
+/- 4 nmol/L for range 20 - 40 nmol/L
+/- 20% for >40 nmol/L
Steroid Laboratory Phone 03 3640 888
For results please contact Canterbury Health Laboratories ph. 03 364 0300.
Reference. Lewis JG, Bason LM & Elder PA. Production and characterisation of monoclonal antibodies to Dehydroepiandrosterone sulphate: application to direct enzyme-linked immunosorbent assays of dehydroepiandrosterone sulphate and androsterone/epiandrosterone sulphates in plasma. Steroids. 61; 1-6, 1996.
Lewis JG, George PM & Elder PA. Plasma androsterone/epiandrosterone sulfates as markers of 5a reductase activity. Steroids. 62: 632-635, 1997