CSF-Oligoclonal Banding, CSF + Serum

Diagnostic Use

The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include the CSF index, IgG synthesis rate and CSF oligoclonal band detection. Abnormal CSF indexes and oligoclonal banding patterns have been reported in 70% to 80% of MS patients. At least 1 of these tests has been reported to be positive in 90% of MS patients when both tests are performed.
Newer methodologies for oligoclonal band detection have been reported to be more sensitive, with sensitivities of 90% to 95% in CSF from MS patients.
Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore, this assay is not specific for MS (specificity = 95%).


Protein Lab

Delphic Registration Code



CSF electrophoresis
CSF IgG synthesis rate
CSF index
Oligoclonal Banding

Turnaround Time

5 days

Test Code