Diagnostic Use

Arginine vasopressin (AVP) and copeptin are derived from the same precursor peptide. Copeptin has been proposed as a more stable, potentially superior, surrogate marker of AVP in the assessment of water balance disorders. Both copeptin and AVP are responsive to osmotic stimuli and increase in response to water deprivation. Copeptin increases gradually with fasting and water deprivation and declines rapidly after intake of water and /or food.

The determination of the underlying disease pathology in patients with polyuria and altered plasma osmolality is often difficult. Polyuria can be related to insufficient AVP (central DI), reduced sensitivity to AVP (nephrogenic DI), or excessive water intake. Measurement of copeptin concentration has been shown to be useful in the investigation of these AVP related disorders.


Specialist Biochemistry

Delphic Registration Code


Turnaround Time

14 days

Test Code