Diagnostic Use

Creutzfeldt-Jakob disease (CJD) is one of the human forms of the transmissible spongiform encephalopathies (TSEs), also referred to as prion diseases. Prion diseases mostly occur as a chance event but can be, in rare cases, attributed to a genetic mutation or acquired through a transmission event.

Those considered at high risk for the condition include patients who report neurological symptoms and display neurological signs of prion disease or have been diagnosed with suspected CJD/prion disease. Symptomatic patients with a recognised health care associated risk factor are also considered to be high risk.

Testing performed at the Florey Institute in Melbourne include the CJD Biomarker Panel 14-3-3 protein ELISA and RT-QuIC assay (Real-time quaking induced conversion; currently not National Association of Testing Authorities (NATA) accredited) and the total-tau protein (NATA accredited).


Microbiology - Virology

Delphic Registration Code


Laboratory Handling


CSF collection in standard CSF collection tube. (Specialist tubes required for collection of CSF for Alzheimer's disease)


CSF Samples requesting 14-3-3 protein for CJD should remain double bagged during the registration process then transported to the virology department directly.


2.5 mL minimum must be received by Virology for transportation to reference centre.


Testing is performed by the Florey Institute in Melbourne, Australia


14-3-3 protein
Creutzfeldt-Jakob disease
Spongiform encephalopathy

Turnaround Time

3 weeks

Test Code