Chylomicrons, which transport dietary and biliary lipids through the lymphatic system to the blood, are the vehicles of exogenous lipid transport of long chain fatty acids and cholesterol.
Chylomicrons are secreted at all times entering circulation and travelling to various tissues. After secretion they acquire additional Apo proteins, including Apo E, apo C-I, apoC-II and apo C-III from HDL in lymph and blood plasma. Chylomicrons bind rapidly to lipoprotein lipase, which is bound to the surface of blood capillaries, mainly in muscle and adipose tissue. This binding is followed by rapid hydrolysis of most of the component triglycerides and some of the phospholipids in the particle. Free fatty acids then become available for the cell to utilise at energy or as building blocks for other biochemicals.
Pleural Fluids - FLUD, LIPE. Plasma - LIPU
4 mL pleural fluid or 2x4 mL EDTA(Lavender)
Chilled (2 - 8 degrees Celsius)
4 mL pleural fluid,serum or plasma. Store fridge
“Pleural fluids with a triglyceride concentration above 1.24 mmol/L have a 99%chance of being chylos whereas those with a concentration below 0.57 mmol/L have no more than a 5% chance.
Lipoprotein electrophoresis may be helpful by confirming the presence of chylomicra.”
Ann Clin Biochem 2001;38:311-22. Tarn AC, Lapworth R.
Not normally detected in a fasting sample.
Pleural fluids have a Cholesterol and Triglyceride and Lipid Electrophoresis only. A Detected or Not Detected comment is added.
Ultracentrifugation for Plasma, Lipid electrophoresis for fluids.
Contact Canterbury Health Laboratories on +64 3 364 0484 or email LabInfo@cdhb.health.nz
Can be tested for in plasma or pleural fluid
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