Detection of microscopically visible chromosome rearrangements (>10Mb) for cases of suspected mosaicism, including tissue-specific aneuploidy such as trisomy 8, Pallister-Killian syndrome [i(12)(p)]
PLEASE NOTE: karyotyping of Fetal Tissues and Products of Conception to investigate fetal loss is no longer routinely performed at this laboratory. Where clinically relevant, testing is now performed firstly by QF-PCR, to screen for common aneuploidy and maternal cell contamination, followed by a MICROARRAY if QF-PCR result is normal.
Indications for QF-PCR+Microarray:
• Recurrent miscarriage (defined as ≥ 3)
• Abnormalities on U/S or abnormal fetal phenotype
• Family history of a chromosomal rearrangement
Genetics - Cytogenetics
Chromosome analysis of tissue
Fetal tissue, cytogenetics
Fibroblast tissue culture
Placenta tissue, chromosomes
Solid Tissue should be collected aseptically in RPMI Tissue Transport Medium in a universal container. In an emergency, the specimen can be collected into sterile saline.
To order transport medium phone the CHL patient and client services 03 364 0484 between 09.00-17.00, Mon-Fri and allow at least one working day for delivery.
Tissue smaller than 1cm x 1cm should be collected aseptically into sterile transport medium (see above).
Larger specimens can be sent dry in a sterile pottle, without delay.
DO NOT REFRIGERATE OR FREEZE
Ambient (8 - 24 degrees Celsius)
Transport to lab ambient. DO NOT REFRIGERATE OR FREEZE
Comment on report
Comment on report
Solid tissue is cleaned, finely chopped and cultured in growth medium for approximately 5-15 days and then harvested at the metaphase stage of the cell cycle when chromosomes are most condensed and visible by light microscopy.
Microscopic analysis (karyotyping) is performed on G-banded chromosome preparations.
Note this test is no longer routinely performed for investigations into FETAL LOSS. Please see below and refer to QF-PCR and Microarray tests for further details. Alternatively contact the lab 03 364 0881.
$651.56 (Exclusive of GST)
Urgent testing by arrangement