CD40 ligand (CD40L)

Diagnostic Use

X linked hyper-IgM (XHIM) syndrome is a primary immunodeficiency caused by mutations in the tumour necrosis factor superfamily 5 gene, TNFSF5, also known as the CD40 ligand (CD40L) or CD154 gene. Patients often present with recurrent infections, and confirmation of a diagnosis of XHIM enables appropriate therapeutic interventions, including replacement immunoglobulin, antibiotics, and bone marrow transplantation.



Delphic Registration Code


Laboratory Handling


Phone lab and send direct to immunology or after hours place into immunology bin at room temperature

Turnaround Time

1 week