CRP is a hepatic protein produced as part of the acute inflammatory response.
Plasma CRP levels are as a non-specific biomarker for inflammation.
A second use for CRP is as a cardiovascular risk biomarker. See high sensitivity CRP for more information.
Ambient (8 - 24 degrees Celsius)
An elevated CRP indicates the presence of inflammation but is not specific for the site, type or source of inflammation. Causes of an elevated CRP include infection, malignancy, trauma and post-surgery.
CRP may be monitored in a patient with an inflammatory condition to assess response to treatment. Because of its longer half-life (approx. 19 hours) CRP generally starts to decrease after the WBC count has started to decrease.
Caution is advised when interpreting CRP levels in a patient with chronic liver disease. Because CRP is synthesised by hepatocytes, CRP levels in patients with cirrhosis may be misleadingly low.
Immunoturbidimetric method on Beckman Coulter AU5822 analyser using Beckman Coulter reagents.
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