Busulfan is an alkylating agent used in preperative regimens associated with bone marrow transplantation. It is the mainstay of treatment for chronic myelogenous leukaemia.
Department
Toxicology
Delphic Registration Code
PDC
Laboratory Handling
Registration
Register each tube on a separate number
Turnaround Time
6 hours
Specimen Type
Serum
Plasma
Specimen Requirements
Tube/Container Type:
Preferred
Serum (Red Cap)
Acceptable
Lithium Heparin - Non-gel (Green Cap)
Preferred Sample Volume (ml)
4.0
No of Samples Required
1
Paediatric Specimen Requirements
Tube/Container Type:
Preferred
Serum (Red Cap)
Acceptable
Lithium Heparin - Non-gel (Green Cap)
Preferred Sample Volume (ml)
1.0
Pre-testing Requirements
Where analysis is done to determine the area under the curve (AUC) for the drug's pharmackinetics, serial samples must be collected. Collect samples at 30 minute intervals for the first hour and a half after administration of the drug and then another level prior to the next dose.
Additional Specimen Information
Do not use SST gel tubes for this analysis
Aliquot Instructions
Sample Type
Serum
Plasma
Minimum Volume (ml)
1.0
Transport to Lab
Chilled (2 - 8 degrees Celsius)
If overnight - Frozen
Interpretation
Contact Pharmacology for determination of AUC and dose advice.
Test Method
LCMSMS
Non-Funded Test Cost
$528.90 (Exclusive of GST)
Billing Code
4741
Test Availability Mon - Fri by prior arrangement only
