Methyl bromide is a gaseous chemical used as a fumigant for large enclosed industrial and agricultural areas. Bromide is also used as a sedative. Bromides act by depressing central nervous system activity and have shown moderate anticonvulsant activity against tonic seizures. They are now very seldom used as anticonvulsants.
Methyl bromide is known to be partially converted to inorganic bromide. The contribution of this metabolite to the toxicity of the parent compound is unclear, but since inorganic blood concentrations after methyl-Br poisoning are generally much lower than during intoxication of bromide salts, it seems likely that the methyl-Br is the primary toxic agent. Toxicity may develop after a latent period of several hours and is manifested by confusion, abdo pain, weakness, nausea, convulsions, coma and occasionally pulmonary edema.
Chilled (2 - 8 degrees Celsius)
Normal bromide concentrations in unexposed people range from 0.03- 0.15 mmol/L, depending on diet.
Plasma levels of 750 – 1000 mg/L have been found to be effective in the treatment of epilepsy, although many patients may show signs of toxicity at these concentrations.
Re Woodbury (1972) in “Disposition of Toxic Drugs and Chemicals in Man”,
Randall C Baselt second edition 1982 Biomedical Publications.
Normal bromide concentrations in unexposed people range from 0.03 – 015 mmol/L depending on diet.
Toxic levels may occur at levels of 0.38 mmol/L (30 mg/L) with severe symptoms at levels of 1.5 mmol/L (120 mg/L).
(Source: National Poisons Centre, Dunedin)
$57.30 (Exclusive of GST)