Beta hydroxybutyrate (bOH-B) is one of the two major ketone bodies produced by the liver as a byproduct of fatty acid metabolism.
Measurement of plasma ketones can be helpful when investigating a high anion gap metabolic acidosis. Causes of ketosis include relative insulin deficiency (e.g. diabetes), alcohol excess and starvation.
Significant positive interference from haemolysis.
Paediatric Specimen - Heparin microtainer 600 µL
Chilled (2 - 8 degrees Celsius)
If overnight - Frozen
Aliquot transport: Serum, plasma stable for 48 hours at 2-8°C.
>48 hours transport frozen (on ice).
An elevated plasma bOH-B is indicative of ketosis. The result should be interpreted in the clinical context and in consideration with the results of other tests such as venous/arterial blood gas and glucose.
The most common cause for a significant ketosis is diabetic ketoacidosis. Diabetic patients taking sodium-glucose cotransporter 2 (SGLT-2) inhibitors may develop a ketoacidosis in the absence of hyperglycaemia (euglycaemic ketoacidosis).
Other causes for ketosis (+/- acidosis) include starvation and alcohol excess.
Patients on a ketogenic diet may develop a mild elevation of plasma bOH-B however it is unlikely that these patients will develop an acidosis.
Kinetic enzymatic method performed on Beckman Coulter AU5822 analyser using Randox reagents.
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