Interpretation
Beta-2 microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility (HLA: human leukocyte antigen) antigens.
Increased urine levels are seen in proximal tubular renal damage due to a variety of causes, including cadmium, mercury, lithium, or aminoglycoside toxicity; pyelonephritis; and Balkan nephropathy, a chronic interstitial nephritis of unknown etiology.
Beta-2 microglobulin excretion is increased 100 to 1000 times normal levels in cadmium-exposed workers.
Test Method
Nephelometric immunoassay by Siemens BNII.