To provide support for the diagnosis of autoimmune encephalitis/Limbic encephalitis through the detection in serum and/or CSF of antigen specific anti-neuronal antibodies.
Where NMDAR antibodies only are required please refer to NMDA/5844 test information
Clinically urgent requests can be expedited only if communicated to Immunology by phone
NMDA, NMDAR, AMPA, GABA, GABAB, LGI1, CASPR2, VGKC, voltage gated
Indirect immunofluorescence is a subjective method therefore maybe subject to uncertainty.
Results are based on presence of absence of detectable antibodies.
|Antibody to||Main syndrome||Clinical Features||Age association|
|NMDA Receptor||NMDAR encephalitis||Children – seizures
Adult – behavioural, psychiatric
Association with ovarian teratoma in women
|Children and adults|
|AMPA||Limbic encephalitis||Confusion, memory loss
Association with SCLC, thymoma or breast cancer
|GABAb R||Limbic encephalitis||Seizures, memory loss, confusion
Association with SCLC
|LGI1||Limbic encephalitis||Memory loss, seizures, hyponatraemia
Association with thymoma
|CASPR2||Limbic encephalitis||Memory loss, insomnia, dysautonomia, ataxia, neuropathic pain||Adult|
Please note, the following antibodies in this panel have not been subject in internal verification due to rarity of samples: AMPA1/GABAb R. Should a positive be detected, sample will be referred for confirmation.
$402.33 (Exclusive of GST)
"*" indicates required fields