Apolipoprotein B (ApoB) is the principal protein component of low-density lipoprotein (LDL). Whilst the amount of cholesterol contained within LDL varies, each LDL particle contains exactly one ApoB protein. Co-measurement of ApoB with LDL enables deduction about LDL particle size and atherogenicity. It is usually only requested within the domain of the Lipid Clinic.
Lithium heparin and EDTA plasma are NOT acceptable.
Chilled (2 - 8 degrees Celsius)
500 uL serum. Fridge 4°C. Minimum 300 uL serum
Co-measurement of ApoB with LDL enables deduction about LDL particle size and atherogenicity. For any given LDL concentration, a higher ApoB concentration implies a greater number of LDL particles, which are smaller and denser, also more atherogenic – sometimes termed ‘pattern B’. Conversely, a lower ApoB concentration implies LDL particles which are larger and less-dense, also less atherogenic.
Measurement may assist in assessing atherogenicity of a lipid profile and response to treatment, although it is rarely requested outside the Lipid Clinic.
ApoB is strongly associated with increased risk of developing cardiovascular disease (CVD) and often outperforms LDL-C at predicting CVD risk in some epidemiological and other studies.
A low apoB may help to corroborate disorders where LDL-cholesterol is very low, eg familial hypo-beta-lipoproteinaemia.
Male reference range 0.52 – 1.09 g/L
Female reference range 0.49 – 1.03 g/L
$17.1 (Exclusive of GST)
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