Apolipoprotein A1, Serum

Diagnostic Use

Apolipoprotein A (ApoA) is the principal protein associated with high-density lipoprotein (HDL) particles, which plays a role in reverse cholesterol transport.

HDL cholesterol (HDL-C) and ApoA concentrations are inversely related to the risk for coronary artery disease (CAD). There are a variable number of ApoA proteins per HDL particle, thus ApoA is not strictly a surrogate marker for HDL-C.

It is not to be confused with lipoprotein (a), which has a fundamentally different role and interpretation.

Department

Lipids/Trace Metals

Delphic Registration Code

APOA

Laboratory Handling

Separating

Separate serum within 4 hours of collection. Aliquot to Lipids / Trace Metals- Fridge

Laboratory

Reject sample if either grossly haemolysed or icteric.

Test Adds

stable ambient 24 hours, refrigerated for 8 days, frozen 60 days.

Synonyms

APO A1

Turnaround Time

5 days

Test Code

4164

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Preferred if West Coast

• SST II (Gold Cap)

Acceptable

• SST II (Gold Cap)

Preferred Sample Volume (ml)

3

No of Samples Required

1

Paediatric Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• SST II (Gold Cap)

Preferred Sample Volume (ml)

1

Additional Specimen Information

Lithium heparin and EDTA plasma are NOT acceptable.

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

0.3

Transport to Lab

Chilled (2 - 8 degrees Celsius)

Additional Referral/Aliquot Information

500 uL serum. Fridge 4°C minimum 300 uL serum.

Interpretation

Although not strictly a surrogate for HDL-C, measurement of ApoA is often used to corroborate very elevated or very low HDL-C concentrations.

It otherwise contributes little above HDL-C to the evaluation of CVD risk and is rarely requested outside the Lipid Clinic.

Reference Intervals

Male reference range 0.94 – 1.78 g/L

Female reference range 1.01 – 1.99 g/L

Test Method

Immunoturbidimetric

Non-Funded Test Cost

$18.13 (Exclusive of GST)

Billing Code

4164

Additional Costing Information

Batched approximately 2 time per week

Contact Information

Enquiry Form