ANA - screen
Ambient (8 - 24 degrees Celsius)
100 uL serum - minimum, 1 mL serum - required. Store in fridge
Systemic autoimmune disease is usually associated with titres greater than 1 in 80.
ANAs are screened at 1 in 80 dilution on Hep2000 cells.
$15.05 (Exclusive of GST)
Anti-nuclear Antibodies - screen
Negative ANA usually rules out (99% sensitive using the 1982 ACR Classification Criteria) a diagnosis of SLE although anti Ro positive SLE patients may be negative. See comments on result reports regarding ANA patterns.
All positive ANA screens will be titred. ANA testing may be added to requests for myositis antibodies, ENA & scleroderma antibody requests to confirm line blot or CIEP results if this has not been performed at CHL.