Amyloid A is an acute phase protein, which in response to inflammatory processes exhibits a rapid increase in its blood concentration up to 1000 fold from its initial concentration. Amyloid A is more conclusive than CRP in patients with viral infections, rejection reactions to kidney transplants as well as in patients with cystic fibrosis treated with corticoids. In the case of inflammatory arthritis, Amyloid A was found to exhibit the closest correlation to the activity of the disease.
One particularly important aspect of Amyloid A is that its degradation products can be deposited in various organs as Amyloid A (AA) fibrils, which is a serious complication in chronic inflammatory diseases.
Serum is stable for no more than 8 days stored at 2 to 8 degrees C.
Samples can be stored frozen at or below -25 degrees C for up to 3 months if they are frozen within 24 hours after collection.
Avoid repeated freezing/thawing.
Chilled (2 - 8 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)
Refrigerated if within 5 days of collection, otherwise frozen.
< 6.4 mg/L
Measurement uncertainty 12%
Quantitation by nephelometric immunoassay on Siemens BNII.
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