Active B12 (holotranscobalamin) is used as an aid in the diagnosis and monitoring of treatment for vitamin B12 deficiency.
Lithium heparin and EDTA blood collection tubes are unacceptable sample types.
Chilled (2 - 8 degrees Celsius)
If overnight - Chilled (2 - 8 degrees Celsius)
Stable 7 days 2-8, if separated from cells.
|<37 pmol/L||Vitamin B12 deficiency is likely.|
|≥37 – <58 pmol/L||
Holotranscobalamin is in the equivocal range. The result should be interpreted
in the context of signs, symptoms, and risk factors for vitamin B12
deficiency. Further measurement of functional markers of vitamin B12 status,
such as serum methylmalonic acid and/or total homocysteine, may be of value.
|≥ 58 pmol/L||Vitamin B12 deficiency is unlikely.|
2.5th -97.5th percentile reference interval: 37.5-150 pmol/L
Roche Electrochemiluminescence immunoassay
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