11 Deoxycortisol, (Serum Only)

Diagnostic Use

Provides a differential diagnosis of one form of Congenital Adrenal Hyperplasia (CAH) caused by a defect in the 11b hydroxylase enzyme. (see 17a hydroxy progesterone)

11 deoxy cortisol also provides an index of pituitary function when cortisol and 11deoxycortisol are used in conjunction with metapyrone test. 11b hydroxylase is inhibited by metapyrone which results in an increase of cpd S and lowering of cortisol due to the cortisol feed back mechanism on action of ACTH from pituitary. Thus results can help assess pituitary and adrenal functions.

Department

Endo/Steroid Lab

Delphic Registration Code

DCOR

Synonyms

Compound S

Turnaround Time

4 weeks

Test Code

5305

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• Serum (Red Cap)
• SST II (Gold Cap)

Preferred Sample Volume (ml)

1

No of Samples Required

1

Paediatric Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Acceptable

• Serum (Red Cap)
• SST II (Gold Cap)

Preferred Sample Volume (ml)

.5

Minimum Sample Volume (ml)

0.3

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

0.3

Transport to Lab

Chilled (2 - 8 degrees Celsius)
Frozen

Additional Referral/Aliquot Information

Aliquot Instructions - Plasma 300 uL. Freeze/refrigerate

Reference Intervals

Random:

Age
<6 years	<8.8 nmol/L
> 6 years	<4.6 nmol/L

 

Metyrapone inhibition:

 

11- Deoxycortisol >200nmol/L – normal

11- Deoxycortisol < 200nmol/L – consistent with secondary adrenal insufficiency

Note: cortisol < 200nmol/L shows that metyrapone inhibition of cortisol and subsequent ACTH stimulation has been adequate (i.e. test interpretable)

Test Method

Liquid Chromatography mass spectrometry (LC-MS/MS)

Non-Funded Test Cost

$150 (Exclusive of GST)

Billing Code

5305

For results please contact Canterbury Health Laboratories ph. 03 364 0300.

Contact Information

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