Where the AUC is to be calculated take blood samples 30 minutes and 6 - 22 hours (depending on renal function) post the end of the infusion recording both the exact time of infusion and blood collection. Repeat the 30 minute and 6 - 22 hour post-infusion blood samples every 3 days or prn depending on the clinical situation.
Do not use SST gel tubes.
Aliquot Instructions
Sample Type
Serum
Plasma
Minimum Volume (ml)
1
Transport to Lab
Chilled (2 - 8 degrees Celsius)
Additional Referral/Aliquot Information
Serum/plasma may be stored at 2-8 degrees Celsius up to 7 days. If testing is delayed more than 7 days, sample is to be stored frozen for up to 14 days.
Reference Intervals
1. A 24-hour AUC of 150 – 200 mg/L.hr if using the target-AUC method (200 mg/L.hr if severe infection).
2. A 24 hour trough concentration of < 2.0 mg/L if the AUC method is not available.
Test Method
Particle enhanced turbidimetric immunoassay on the Beckman Coulter AU5800
