Serial/Synacthen 17-OH Progesterone (Red Top Serum Only)

Diagnostic Use

For use in the diagnosis of congenital adrenal hyperplasia (CAH).
The commonest form of CAH is caused by a deficiency of the enzyme 21-hydroxylase, leading to an excessive secretion of the cortisol precursor steroid, 17-hydroxyprogesterone.

Department

Endocrinology Lab

Delphic Registration Code

OHP1 (PRE) and OHP2 (POST)

Laboratory Handling

Phlebotomy

Please label tubes with collection time and either PRE or POST. There may be more than one POST sample collected.

Synonyms

Synacthen
OHPR

Turnaround Time

14 days

Specimen Type

• Serum

Specimen Requirements

Tube/Container Type:

Preferred

• Serum (Red Cap)

Preferred if West Coast

• Serum (Red Cap)

Preferred Sample Volume (ml)

1

Aliquot Instructions

Sample Type

• Serum

Minimum Volume (ml)

0.6

Transport to Lab

Ambient (8 - 24 degrees Celsius)

Interpretation

Interpretation of serial Synacthen stimulated 17OHPR

17OHP Synacthen test – Adult patients ≥ 16 years
Basal (nmol/L)	60 min post (nmol/L)	Interpretation
<6	<9.0	Normal response
	9-30	Possible heterozygote – consider CYP21A2 genotyping
	>30	Consistent with CAH secondary to 21-hydroxylase deficiency

 

Reference Intervals

Diagnosis of Congenital Adrenal Hyperplasia.

Non-Funded Test Cost

$125.97 (Exclusive of GST)

Billing Code

3735

Contact Information

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