Nucleophosmin

Diagnostic Use

Test to determine if a NPM1 mutation is present in the NPM1 gene of AML patients.
This provides prognostic information at diagnosis and can also be used for MRD monitoring.
Note that this assay is not for MRD monitoring.

Department

Genetics - Molecular Oncology

Delphic Registration Code

MONC

Laboratory Handling

Phlebotomy

2x EDTA (Lavender) dedicated to Genetics (same sample can be used for FLT3/NPM1/CEBPA testing)

Registration

Send to MONC

Turnaround Time

7 days

Test Code

7675

Specimen Type

• Whole Blood
• Bone Marrow

Specimen Requirements

Tube/Container Type:

Preferred

• EDTA (Lavender Cap)

Acceptable

• RPMI (Bone Marrow)

Additional Specimen Information

8 ml peripheral blood in EDTA. 1-3 ml of bone marrow in EDTA or RPMI (anticoagulant).
Send ambient to the laboratory.

Aliquot Instructions

Reference Intervals

NPM1 Negative or Positive.

Test Method

PCR amplification of the terminal exon (exon 12) of the NPM1 gene, followed by fragment analysis to detect the NPM1 insertion/deletion variants.
NPM1 variants are characterised by Sanger sequencing.

Non-Funded Test Cost

$330.82 (Exclusive of GST)

Billing Code

7675

Additional Costing Information

Urgent tests can be prioritised.

Contact Information

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