Anti-myeloperoxidase (MPO) antibodies are primarily associated with ANCA-associated vasculitis, most commonly microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA).
Presence of antibodies aids diagnosis; in patients with known disease, measurement of antibody concentrations over time can be used as a prognostic indicator and may be useful in identification of disease flare and remission.
The clinical relevance of anti-MPO outside of vasculitis (e.g. inflammatory bowel disease) is uncertain.
Anti-PR3, with anti-MPO testing is automatically reflexed internally from indirect immunofluorescence ANCA testing.
For urgent/rapid testing (vasculitis screen MPO,PR3 and GBM) please telephone the Immunology laboratory.
Please note method change from 27/10/2023; different measurement units apply, quantitative results between methods are NOT comparable.
Immunology
MPO
MPO Antibodies
MPO-ANCA
MPO
5 days
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