Hypersensitivity to abacavir (an anti-retroviral drug) affects about 4% of patients who receive the drug for HIV-1 infection.
Abacavir hypersensitivity is an immune-mediated reaction that typically occurs within the first 6 weeks of therapy. Signs and symptoms of abacavir hypersensitivity are nonspecific, which makes the diagnosis challenging, but can present with any of the following symptoms: Fever, Rash, GI, malaise or respiratory. Continuation on abacavir after hypersensitivity presents can be fatal.
Susceptibility to a clinically significant hypersensitivity syndrome associated with abacavir use seems to have a strong genetic component where the presence of HL-B*5701 is strongly predicitive of hypersensitivity.
Genetics - Molecular Pathology
B701
abacavir sensitivity
HIV
4 weeks
6419